Attenuation of Cisplatin-induced Emetogenesis by Standardized Bacopa Monniera Extracts in the Pigeon: Behaviovral and Neurochemical Correlations
نویسندگان
چکیده
Nausea and vomiting are the most distressing and common side effects of cancer chemotherapy which often result in patient non-compliance. In the present study, standardized methanolic fractions of Bacopa monniera (BM) were evaluated against cisplatin induced emesis in the pigeon in relation to their activity on central and intestinal neurotransmitter levels. Cisplatin (7.0 mg/kg, i.v.) induced reproducible emesis without lethality in healthy pigeons. The methanolic (10–40 mg/kg), the bacoside rich n-butanolic fractions of B. monniera (5–20 mg/kg) as well as the antioxidant N-(2-Mercaptoprpionyl) glycine (10 mg/kg) attenuated cisplatin induced emesis by 66.3% (P<0.05), 71.6% (P<0.001) and 76.5% (P<0.001), respectively; where the standard antiemetic, metoclopramide (30 mg/kg), produced a 48.9%
منابع مشابه
Attenuation of cisplatin-induced emetogenesis by standardized Bacopa monnieri extracts in the pigeon: behavioral and neurochemical correlations.
Nausea and vomiting are the most distressing and common side effects of cancer chemotherapy which often result in patient noncompliance. In the present study, standardized methanolic and n-butanolic fractions of Bacopa monnieri were evaluated against cisplatin-induced emesis in the pigeon in relation to their activity on central and intestinal neurotransmitters levels. Cisplatin (7.0 mg/kg, i. ...
متن کاملEffect of chlorophyll and aqueous extracts of Bacopa monniera and Valeriana wallichii on ischaemia and reperfusion-induced cerebral injury in mice.
Bilateral carotid artery occlusion followed by reperfusion produced significant cerebral infarction and impaired short-term memory, motor co-ordination and lateral push response. Individual pretreatments with chlorophyll and aqueous extracts of B. monniera and V. wallichii markedly attenuated ischaemia-reperfusion induced cerebral injury in terms of decreased infarct size, increase in short-ter...
متن کاملExperimental and Clinical Evaluation of Nootropic Activity of Bacopa monniera Linn. (Brahmi)
Bacopa monniera Linn. (Brahmi) is an annual creeper belonging to family Scrophulariaceae and growing all over the Indian sub-continent in marshy areas. It is a major Medhya Rasayana used in Ayurveda for treatment of memory disorders. Large number of saponins and glycosides has been isolated from the plant. Most of the experimental and clinical studies have been done with crude extracts or stand...
متن کاملEffect of Induced Oxidative Stress and Herbal Extracts on Acid Phosphatase Activity in Lysosomal and Microsomal Fractions of Midgut Tissue of the Silkworm, Bombyx mori
Lysosomal and microsomal acid phosphatase activity was estimated in midgut tissue of silkworm larvae, Bombyx mori L. (Lepidoptera: Bombycidae), after induced oxidative stress by D-galactose. The larvae were simultaneously were treated with ethanolic extracts of Bacopa monniera and Lactuca sativa to study their antioxidant properties. Lipid peroxidation and fluorescence was measured to analyze e...
متن کاملAnxiolytic activity of a standardized extract of Bacopa monniera: an experimental study.
Bacopa monniera Wettst. (syn. Herpestis monniera L.; Hindi - Brahmi) is classified in Ayurveda, the classical Indian system of medicine, as Medhyarasayana, a group of plant derived drugs used as nervine tonics to promote mental health and improve memory and intellect. Earlier experimental and clinical studies have demonstrated the memory-promoting action of the plant extracts and that of its ac...
متن کامل